Established Use With Industry-Leading Partners
Epiontis ID has been used in phase 1 to phase 3 studies by some of the most prominent biopharmaceutical companies around the world.
Use of Epigenetic Cell Counting to Determine the Effect of Ozanimod on Circulating Leukocyte Subtypes in Patients With Relapsing Multiple Sclerosis
Phase 1 Study by Celgene/BMS for Ozanimod, 2019
Effects on CD3, Treg, and TH17 Cell Numbers in Skin Biopsies After 16-Week Mirkizumab Treatment, Evaluated by an Epigenetic Assay
Phase 2 Study by Eli Lilly for Mirikizumab, 2019
Quantifying Circulating Th17 Cells by qPCR: Potential as a Diagnostic Biomarker for Rheumatoid Arthritis
Publication in Rheumatology, 2019
Interim Biomarker Analysis of Etigilimab (OMP-313M32), an Anti-TIGIT Antibody, in Advanced Solid Tumors Supports TIGIT-associated Mechanisms of Action
Selective Induction of Activated Regulatory T-Cells in Healthy Volunteers by NKTR-358, a Novel IL-2 Conjugate Treg Stimulator, in Development for the Treatment of Autoimmune Diseases
Two Posters on Parallel Use of Flow Cytometry and Epiontis ID in Oncology, Nektar and Oncomed, 2019
Selection of Recent Publications
-
Epigenetic immune cell counting in human blood samples for immunodiagnostics.
Science Translational Medicine
Baron U, Werner J, Schildknecht K, et al. Epigenetic immune cell counting in human blood samples for immunodiagnostics. Sci Transl Med. 2018;10(452):eaan3508. doi: 10.1126/scitranslmed.aan3508. -
Quantifying circulating Th17 cells by qPCR: potential as diagnostic biomarker for rheumatoid arthritis.
Rheumatology (Oxford)
Burska AN, Thu A, Parmar R, et al. Quantifying circulating Th17 cells by qPCR: potential as diagnostic biomarker for rheumatoid arthritis. Rheumatology (Oxford). 2019;58(11):2015-2024. doi: 10.1093/rheumatology/kez162. -
Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology.
Rheumatology (Oxford)
Blokland SLM, van Vliet-Moret FM, Hillen MR, et al. Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology. Rheumatology (Oxford). 2020;59(2):335-343. doi: 10.1093/rheumatology/kez268. -
Treatment with rapamycin can restore regulatory T-cell function in IPEX patients.
Journal of Allergy and Clinical Immunology
Passerini L, Barzaghi F, Curto R, et al.Treatment with rapamycin can restore regulatory T-cell function in IPEX patients. J Allergy Clin Immunol. 2020;145(4):1262-1271.e13. doi:10.1016/j.jaci.2019.11.043. Epub 2019 Dec 23. -
Circulating immune cell composition and cancer risk: a prospective study using epigenetic cell count measures.
Cancer Research
Le Cornet C, Schildknecht K, Rossello Chornet A, et al. Circulating immune cell composition and cancer risk: a prospective study using epigenetic cell count measures. Cancer Res. 2020;80(9):1885-1892. doi: 10.1158/0008-5472.CAN-19-3178. Epub 2020 Feb 19. -
Human LAP+GARP+FOXP3+ regulatory T cells attenuate xenogeneic graft versus host disease.
Theranostics
Wang H, Song H, Pham AV, et al. Human LAP+GARP+FOXP3+ regulatory T cells attenuate xenogeneic graft versus host disease. Theranostics. 2019;9(8):2315-2324. doi: 10.7150/thno.30254.